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and both the EPA and the Agency for Toxic Substances and Disease Registry consider endosulfan to be a potential endocrine disruptor.Numerous in vitro studies have documented its potential to disrupt hormones and animal studies have demonstrated its reproductive and developmental toxicity, especially among males.Specifically, it is produced by the Diels-Alder reaction of hexachlorocyclopentadiene with cis-butene-1,4-diol and subsequent reaction of the adduct with thionyl chloride.

The ban has taken effect in mid-2012, with certain uses exempted for five additional years.No epidemiological studies link exposure to endosulfan specifically to cancer in humans, but in vitro assays have shown that endosulfan can promote proliferation of human breast cancer the Department of Biochemistry, Indian Institute of Science, Bangalore published in Carcinogenesis, Endosulfan was found to induce reactive oxygen species (ROS) in a concentration and time-dependent manner leading to double-stranded breaks in the DNA and also found to favour subsequent erroneous DNA repair.For example, a 2008 report by the National Park Service found that endosulfan commonly contaminates air, water, plants, and fish of national parks in the US.Most of these parks are far from areas where endosulfan is used.

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